A Space-Time Conditional Intensity Model for Invasive Meningococcal Disease Occurrence

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A space-time conditional intensity model for invasive meningococcal disease occurrence.

A novel point process model continuous in space-time is proposed for quantifying the transmission dynamics of the two most common meningococcal antigenic sequence types observed in Germany 2002-2008. Modeling is based on the conditional intensity function (CIF), which is described by a superposition of additive and multiplicative components. As an epidemiological interesting finding, spread beh...

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Web - based Supplementary Materials for “ A space - time conditional intensity model for invasive meningococcal disease occurence ”

Sebastian Meyer1,2, Johannes Elias3, and Michael Höhle4,2 1Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität, München, Germany 2Department of Statistics, Ludwig-Maximilians-Universität, München, Germany 3German Reference Centre for Meningococci, University of Würzburg, Würzburg, Germany 4Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany

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A space-time conditional intensity model for infectious disease occurence

A space-time conditional intensity model for infectious disease occurence Summary. A novel point process model continuous in space-time is proposed for infectious disease data. Modelling is based on the conditional intensity function (CIF) and extends an additive-multiplicative CIF model previously proposed for discrete space epidemic modelling. Estimation is performed by means of full maximum ...

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Space-Time Cluster Analysis of Invasive Meningococcal Disease

Clusters are recognized when meningococcal cases of the same phenotypic strain (markers: serogroup, serotype, and subtype) occur in spatial and temporal proximity. The incidence of such clusters was compared to the incidence that would be expected by chance by using space-time nearest-neighbor analysis of 4,887 confirmed invasive meningococcal cases identified in the 9-year surveillance period ...

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Invasive meningococcal disease (IMD) is a severe bacterial infectious disease with high mortality and morbidity rates worldwide. In recent years, industrialised countries have implemented vaccines targeting IMD in their National Immunisation Programmes (NIPs). In 2002, the Netherlands successfully implemented a single dose of meningococcal serogroup C conjugate vaccine at the age of 14 months a...

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ژورنال

عنوان ژورنال: Biometrics

سال: 2011

ISSN: 0006-341X

DOI: 10.1111/j.1541-0420.2011.01684.x